Research in primary care

Our mission is to ensure primary care guidelines are also based on patients from primary care. To bridge the differences between uniform patient populations studied, and the diverse patients in primary care, GPRI facilitates research in, among others, general practices and pharmacies.

GPRI is initiated by two general practitioners and one health economist, all with a passion for scientific research in primary care. In new studies, we always evaluate its potential to improve current guidelines. We then investigate the potential approach of the study and how to make it as pragmatic and accessible as possible.

Because multiple general practices, pharmacies, or other study locations are needed to perform a study in primary care, execution requires an extensive organization process. GPRI functions as a collecting point where practices from primary care can connect as part of scientific research. GPRI functions across national borders having established a global collaboration within primary care.

The circle is complete when a study is finished and outcomes are published, often in well-known scientific journals. After publication we aim to integrate new knowledge in guidelines for primary care. Our current publications can be found here.

What kind of research do we perform?

GPRI facilitates different types of research.

  • In observational studies, no intervention or treatment is investigated but patients are observed. An example of one of the completed observational studies is the PIFotal COPD study in which inhalation technique and inhalation flow were assessed.
  • In interventional studies, also known as clinical studies, the effect of treatment or a medical intervention in patients is investigated. By comparing two groups of patients with each other – the intervention group and the control group – we can assess whether the intervention group exhibits the desired effect. An example of this is the ACCEPTANCE study in which half of the participants are given a smart inhaler to determine if this improves the treatment and reduces asthma symptoms.
  • Questionnaires are frequently used for diagnosis. We develop and validate questionnaires to assess whether they can be properly applied in the field. We are for example working on the SADT project for which we develop a questionnaire on small airway disfunction.
  • In database studies, we analyze existing data sets to arrive at new insights.

Our focus

GPRI primarily focuses on chronic medical conditions. Someone with a chronic medical condition has suffered from the same condition for a long time and the condition cannot be cured with drugs. Currently we are working on research on Asthma, COPD, cardiovascular diseases, urinary tract disease, diabetes and chronic pain.

Current

ACCEPTANCE

Smart inhaler for treatment of asthma

Indication
Asthma that is being treated with Symbicort Turbuhaler as maintenance treatments

Study type
Cluster randomised trial

Target audience
Patients of 18 years and older, General Practitioners and practice nurses 

Additional information
Visit www.acceptance-onderzoek.nl for additional information on this study, contact details and possibilities to enroll

CAPTURE-study

CAPTURE-study

Indication
Insufficiently controlles asthma in primary care

Study type
Prospective observationsal study and qualitative semi-structured interviews

Target audience
General Practitioners and practice nurses

Timelines
Startdate: day month
You can enroll until day month

Additional information
Visit www.gpri.nl/capture for additional information on this study, contact details and possibility to enroll. 

CCQ Graphical

Validation of graphical CCQ questionnaire

Indication
Stable COPD

Study type
Healthcare improvement project with qualitative structured interviews. 

Target audience
Patients of 40 years and over

Additional information
Contact us for additional information on this study. 

COPD comorbidities

Identification of medication-comorbidities clashes

Indication
COPD or lung emphysema with 1 or more co-morbidities

Study type
Pragmatic cluster randomised trial

Target audience
General Practitioners and practice nurses

Additional information
Visit www.gpri.nl/desktophelper for additional information, contact details and possibility to enroll

POSSIBILITY

Perceptions on self-administration injections of biologicals

Indication
Asthma that is being treated or will be treated with biologicals

Study type
Qualitative multi-country study with focus groups and semi-structured interviews. 

Target audience
Patients, lung physicians and nurses. 

Additional information
Contact us for additional information on this study and publications.  

SADT

Small Airway Disease Test

Indication
Small airway disfunction

Study type
Questionnaire development

Target audience
None, we expect to finalise the questionnaire development in November 2021.

Additional information
Contact us for additional information on this study and publications. 

SALINE

Early identification of chronic kidney disease

Indication
Early identification of chronic kidney disease

Study type
Cross-sectional observational study

Target audience
Pharmacists and General Practitioners

Additional information
Visit www.gpri.nl/saline for additional information on this study, contact details and possibilities to enlist.

Spiro@Home

Spirometry measurements at home

Indication
Conditions for which spirometry by the general practitioner is indicated

Study type
Prospective implementation study with semi-structured interviews

Target audience
General Practitioners and research nurses

Additional information
Visit www.gpri.nl/spiro-home for addition information on this study, contact details and possibilities to enroll. 

TRACkER

Triple therapy for patients with COPD

Indication
Symptomatic COPD

Study type
Randomised real-life study

Target audience
Lung physicians, General Practitioners, Practice nurses and patients of 40 years and over

Additional information
Visit www.trackerstudie.nl for additional information on this study, contact details and possibilities to enroll.

Finished

COPPER

COVID-19 in primary care

Indication
Moderate severe COVID-19

Study type
Randomised interventional open-label study

Target audience
General Practitioners of the HZD in Drenthe 

Additional information
Visit www.copper-onderzoek.nl for additional information on this study, publications and contact details. 

PIFotal

Optimizing inhalation therapy in COPD patients

Indication
COPD which is being treated with dry powder inhalers as maintenance treatment

Study type
Cross-sectional, non-interventional multi-center, multi-country study

Target audience
Pharmacies, General Practitioners and practice nurses

Additional information
Visit www.pifotal.com for additional information on this study, publications and contact details.  

PRIME COPD

Profiling inhalation medication in COPD

Indication
COPD

Study type
Retrospective cross-sectional real-life database studie

Target audience
None, database-study

Additional information
Contact us for additional information on this study and publications.