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Health status in patients with limited health literacy; development and validity of the Clinical COPD Questionnaire graphic (CCQg).

Patients with Chronic Obstructive Pulmonary Disease (COPD) often experience limited health literacy, hampering health status assessment via standard...

Identifying critical inhalation technique errors in Dry Powder Inhaler use in patients with COPD based on the association with health status and exacerbations: findings from the multi-country cross-sectional observational PIFotal study.

Correct inhaler use depends on a complex interplay of factors, including device preparation and generating sufficient inspiratory flow. It is...

Development of a tool to detect small airways dysfunction in asthma clinical practice.

Small airways dysfunction (SAD) in asthma is difficult to measure and a gold standard is lacking. The aim of this study was to develop a simple tool...

European Respiratory Society guidelines for the diagnosis of asthma in adults.

Although asthma is very common, affecting 5-10% of the population, the diagnosis of asthma in adults remains a challenge in the real world, which...

Accounting for seasonal variation of nasal gene expression improves transcriptome analysis of asthma.

Environmental seasonal changes, including allergen exposure, pollutants, and viral prevalence, impact gene expression across human tissues....

A Proposed Consensus Definition of Severe COPD: a modified Delphi Study.

Advanced interventions are available for patients with more severe COPD despite guideline-recommended therapies, yet this population is...

Participant Experience, Acceptability and Feasibility of Virtual and Digitally Supported Visits in a Phase IIa COPD Trial.

Understanding participant experience is crucial for improving participant satisfaction, retention, data quality, and clinical trial efficiency;...

Chronic obstructive pulmonary disease and risk of incident cardiovascular disease, chronic kidney disease, and death: a systematic review and meta-analysis.

Chronic obstructive pulmonary disease (COPD) is associated with cardiovascular disease and chronic kidney disease, but with conflicting estimates. We...

A phase 2a, double-blind, randomised, placebo-controlled trial of the myeloperoxidase inhibitor, mitiperstat, in participants with chronic obstructive pulmonary disease.

Neutrophilic inflammation is a common feature of chronic obstructive pulmonary disease (COPD). Mitiperstat, an inhibitor of myeloperoxidase expressed...

Small airway disease predicts exacerbation risk in well-controlled, but not in poorly-controlled asthma: A post hoc analysis of the ATLANTIS study.

Diagnostic adequacy of COPD in primary care: a population-based analysis of spirometry use and risk-factor documentation.

Diagnosing COPD in primary care remains challenging, with significant international evidence of underdiagnosis, misdiagnosis and miscoding. How...

Inhaled triple therapy in symptomatic individuals who currently smoke cigarettes with preserved FEV1/FVC ratio: the CHRONOS clinical trial.