Does mixing inhaler devices lead to unchecked inhaler technique errors in patients with COPD? Findings from the cross-sectional observational MISMATCH study.
BMJ Open Respir Res. 2023 Dec;10(1)Patients with chronic obstructive pulmonary disease (COPD) may be prescribed multiple inhalers that require different techniques for optimal...
Lees meerIdentifying critical inhalation technique errors in Dry Powder Inhaler use in patients with COPD based on the association with health status and exacerbations: findings from the multi-country cross-sectional observational PIFotal study.
BMC Pulm Med. 2023 Aug;23(1):302Correct inhaler use depends on a complex interplay of factors, including device preparation and generating sufficient inspiratory flow. It is...
Lees meerDevelopment of a tool to detect small airways dysfunction in asthma clinical practice.
Eur Respir J. 2023 Mar;61(3)Small airways dysfunction (SAD) in asthma is difficult to measure and a gold standard is lacking. The aim of this study was to develop a simple tool...
Lees meerFactors associated with health status and exacerbations in COPD maintenance therapy with dry powder inhalers.
NPJ Prim Care Respir Med. 2022 May;32(1):18The study aimed to determine the associations of Peak Inspiratory Flow (PIF), inhalation technique and adherence with health status and exacerbations...
Lees meerEuropean Respiratory Society guidelines for the diagnosis of asthma in adults.
Eur Respir J. 2022 Sep;60(3)Although asthma is very common, affecting 5-10% of the population, the diagnosis of asthma in adults remains a challenge in the real world, which...
Lees meerAssociation of stepping-up to high dose inhaled corticosteroids and risk of future asthma exacerbations: data from the US.
J Allergy Clin Immunol Pract. 2025 Oct;Real-world data on the benefit of high-dose inhaled corticosteroid (ICS) post-exacerbation are limited.
Lees meerAssessment of the role of small airway dysfunction in relation to exacerbation risk in patients with well controlled asthma (ATLANTIS): an observational study.
Lancet Respir Med. 2025 Nov;13(11):990Recent surveys suggest that asthma remains inadequately controlled in more than 50% of adults with asthma despite guideline-based standard therapy....
Lees meerPhase 2a, Randomized Trial of Mitiperstat Versus Placebo in Patients with COPD at High Risk of Exacerbation (CRESCENDO).
Int J Chron Obstruct Pulmon Dis. 2025 ;20:3305Neutrophilic inflammation, a key feature of chronic obstructive pulmonary disease (COPD), is associated with exacerbations and poor outcomes....
Lees meerFeasibility, quality and added value of unsupervised at-home spirometry in primary care.
NPJ Prim Care Respir Med. 2025 Sep;35(1):42At-home spirometry could provide added value for the diagnosis and monitoring of obstructive pulmonary disease in primary care. However, it is...
Lees meerExpert Perspectives on Next Generation Health Guidelines: How to Integrate RWE in EBM.
Pragmat Obs Res. 2025 ;16:169Integrating real-world evidence (RWE) into evidence-based medicine (EBM) enhances healthcare decision-making. RWE provides insights into the...
Lees meerDetecting Small Airways Dysfunction in Asthma: Rationale, Findings, and Future of ATLANTIS.
J Allergy Clin Immunol Pract. 2025 Aug;Small airway dysfunction (SAD) is both common and clinically relevant in patients with asthma. However, there is no recognized "gold standard"...
Lees meerAdherence to inhaled corticosteroid medications after an asthma exacerbation and the risk of subsequent exacerbations.
Ann Allergy Asthma Immunol. 2025 Aug;Data on the duration of improved adherence to controller medications after an exacerbation and its impact on asthma outcomes are inconsistent.
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