Does mixing inhaler devices lead to unchecked inhaler technique errors in patients with COPD? Findings from the cross-sectional observational MISMATCH study.
BMJ Open Respir Res. 2023 Dec;10(1)Patients with chronic obstructive pulmonary disease (COPD) may be prescribed multiple inhalers that require different techniques for optimal...
Lees meerIdentifying critical inhalation technique errors in Dry Powder Inhaler use in patients with COPD based on the association with health status and exacerbations: findings from the multi-country cross-sectional observational PIFotal study.
BMC Pulm Med. 2023 Aug;23(1):302Correct inhaler use depends on a complex interplay of factors, including device preparation and generating sufficient inspiratory flow. It is...
Lees meerDevelopment of a tool to detect small airways dysfunction in asthma clinical practice.
Eur Respir J. 2023 Mar;61(3)Small airways dysfunction (SAD) in asthma is difficult to measure and a gold standard is lacking. The aim of this study was to develop a simple tool...
Lees meerFactors associated with health status and exacerbations in COPD maintenance therapy with dry powder inhalers.
NPJ Prim Care Respir Med. 2022 May;32(1):18The study aimed to determine the associations of Peak Inspiratory Flow (PIF), inhalation technique and adherence with health status and exacerbations...
Lees meerEuropean Respiratory Society guidelines for the diagnosis of asthma in adults.
Eur Respir J. 2022 Sep;60(3)Although asthma is very common, affecting 5-10% of the population, the diagnosis of asthma in adults remains a challenge in the real world, which...
Lees meerHealth status in patients with limited health literacy; development and validity of the Clinical COPD Questionnaire graphic (CCQg).
NPJ Prim Care Respir Med. 2026 Jan;36(1):1Patients with Chronic Obstructive Pulmonary Disease (COPD) often experience limited health literacy, hampering health status assessment via standard...
Lees meerNasal gene expression shows a distinct signature in T2-high asthma but not in T2-low disease.
J Allergy Clin Immunol. 2026 Jan;T2-low asthma is defined by low levels of type 2 inflammation and is associated with resistance to inhaled corticosteroids. Its molecular mechanisms...
Lees meerDerivation and Definitions of Clinical Study Variables for Multiple Long Term Conditions in Patients with Chronic Obstructive Pulmonary Disease: Protocol for a Modified Delphi Methods and Consensus Study on Behalf of the International Cardiovascular and Respiratory Alliance.
Pragmat Obs Res. 2025 ;16:243Standardized variables and their definitions are essential for robust delivery and reporting of clinical studies and quality improvement in chronic...
Lees meerCluster Analysis to Identify Distinct Asthma Phenotypes in the ATLANTIS Cohort.
Allergy. 2026 Jan;81(1):185Previous cluster analyses have identified subgroups of asthma. However, only a few studies included parameters of small airways dysfunction (SAD), or...
Lees meerAssociation of Stepping Up to High-Dose Inhaled Corticosteroids and Risk of Future Asthma Exacerbations: Data From the United States.
J Allergy Clin Immunol Pract. 2025 Oct;Real-world data on the benefit of high-dose inhaled corticosteroid (ICS) after exacerbation are limited.
Lees meerAssessment of the role of small airway dysfunction in relation to exacerbation risk in patients with well controlled asthma (ATLANTIS): an observational study.
Lancet Respir Med. 2025 Nov;13(11):990Recent surveys suggest that asthma remains inadequately controlled in more than 50% of adults with asthma despite guideline-based standard therapy....
Lees meerPhase 2a, Randomized Trial of Mitiperstat Versus Placebo in Patients with COPD at High Risk of Exacerbation (CRESCENDO).
Int J Chron Obstruct Pulmon Dis. 2025 ;20:3305Neutrophilic inflammation, a key feature of chronic obstructive pulmonary disease (COPD), is associated with exacerbations and poor outcomes....
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