Nasal gene expression shows a distinct signature in type 2-high asthma but not in type 2-low disease.
J Allergy Clin Immunol. 2026 Jan;Type 2 (T2)-low asthma is defined by low levels of T2 inflammation and is associated with resistance to inhaled corticosteroids. Its molecular...
Lees meerDerivation and Definitions of Clinical Study Variables for Multiple Long Term Conditions in Patients with Chronic Obstructive Pulmonary Disease: Protocol for a Modified Delphi Methods and Consensus Study on Behalf of the International Cardiovascular and Respiratory Alliance.
Pragmat Obs Res. 2025 ;16:243Standardized variables and their definitions are essential for robust delivery and reporting of clinical studies and quality improvement in chronic...
Lees meerCluster Analysis to Identify Distinct Asthma Phenotypes in the ATLANTIS Cohort.
Allergy. 2026 Jan;81(1):185Previous cluster analyses have identified subgroups of asthma. However, only a few studies included parameters of small airways dysfunction (SAD), or...
Lees meerAssociation of Stepping Up to High-Dose Inhaled Corticosteroids and Risk of Future Asthma Exacerbations: Data From the United States.
J Allergy Clin Immunol Pract. 2026 Jan;14(1):122Real-world data on the benefit of high-dose inhaled corticosteroid (ICS) after exacerbation are limited.
Lees meerAssessment of the role of small airway dysfunction in relation to exacerbation risk in patients with well controlled asthma (ATLANTIS): an observational study.
Lancet Respir Med. 2025 Nov;13(11):990Recent surveys suggest that asthma remains inadequately controlled in more than 50% of adults with asthma despite guideline-based standard therapy....
Lees meerPhase 2a, Randomized Trial of Mitiperstat Versus Placebo in Patients with COPD at High Risk of Exacerbation (CRESCENDO).
Int J Chron Obstruct Pulmon Dis. 2025 ;20:3305Neutrophilic inflammation, a key feature of chronic obstructive pulmonary disease (COPD), is associated with exacerbations and poor outcomes....
Lees meerFeasibility, quality and added value of unsupervised at-home spirometry in primary care.
NPJ Prim Care Respir Med. 2025 Sep;35(1):42At-home spirometry could provide added value for the diagnosis and monitoring of obstructive pulmonary disease in primary care. However, it is...
Lees meerExpert Perspectives on Next Generation Health Guidelines: How to Integrate RWE in EBM.
Pragmat Obs Res. 2025 ;16:169Integrating real-world evidence (RWE) into evidence-based medicine (EBM) enhances healthcare decision-making. RWE provides insights into the...
Lees meerDetecting Small Airways Dysfunction in Asthma: Rationale, Findings, and Future of ATLANTIS.
J Allergy Clin Immunol Pract. 2026 Jan;14(1):56Small airway dysfunction (SAD) is both common and clinically relevant in patients with asthma. However, there is no recognized "gold standard"...
Lees meerAdherence to inhaled corticosteroid medications after an asthma exacerbation and the risk of subsequent exacerbations.
Ann Allergy Asthma Immunol. 2026 Feb;136(2):160Data on the duration of improved adherence to controller medications after an exacerbation and its impact on asthma outcomes are inconsistent.
Lees meerThe Burden of COPD with Type 2 Inflammation in North-West Continental Europe.
Int J Chron Obstruct Pulmon Dis. 2025 ;20:2767Chronic obstructive pulmonary disease (COPD) is a complex and heterogeneous disease that places a huge burden on patients, health systems and...
Lees meerUsing 21 century diagnostics to overcome barriers for lung function testing in primary care: it is time to consider oscillometry.
NPJ Prim Care Respir Med. 2025 Aug;35(1):38Obstructive airways diseases, including asthma and COPD as the most commonly encountered respiratory diseases in primary care, are both diagnosed by...
Lees meer