Does mixing inhaler devices lead to unchecked inhaler technique errors in patients with COPD? Findings from the cross-sectional observational MISMATCH study.
BMJ Open Respir Res. 2023 Dec;10(1)Patients with chronic obstructive pulmonary disease (COPD) may be prescribed multiple inhalers that require different techniques for optimal...
Lees meerIdentifying critical inhalation technique errors in Dry Powder Inhaler use in patients with COPD based on the association with health status and exacerbations: findings from the multi-country cross-sectional observational PIFotal study.
BMC Pulm Med. 2023 Aug;23(1):302Correct inhaler use depends on a complex interplay of factors, including device preparation and generating sufficient inspiratory flow. It is...
Lees meerDevelopment of a tool to detect small airways dysfunction in asthma clinical practice.
Eur Respir J. 2023 Mar;61(3)Small airways dysfunction (SAD) in asthma is difficult to measure and a gold standard is lacking. The aim of this study was to develop a simple tool...
Lees meerFactors associated with health status and exacerbations in COPD maintenance therapy with dry powder inhalers.
NPJ Prim Care Respir Med. 2022 May;32(1):18The study aimed to determine the associations of Peak Inspiratory Flow (PIF), inhalation technique and adherence with health status and exacerbations...
Lees meerEuropean Respiratory Society guidelines for the diagnosis of asthma in adults.
Eur Respir J. 2022 Sep;60(3)Although asthma is very common, affecting 5-10% of the population, the diagnosis of asthma in adults remains a challenge in the real world, which...
Lees meerDevelopment and Internal Validation of a Prediction Model for Major Cardiovascular and Respiratory Events in Chronic Obstructive Pulmonary Disease: Nationwide Primary Care Electronic Medical Records Cohort Study.
Pragmat Obs Res. 2026 ;17:551291Cardiovascular diseases are prevalent in individuals with chronic obstructive pulmonary disease (COPD), but current cardiovascular risk assessment...
Lees meerNasal Airway Transcriptome Reflects Selected Asthma-Associated Gene Signatures in the Lower Airways.
Allergy. 2026 Mar;Transcriptomic analysis of bronchial brushes reveals asthma-associated gene signatures but is limited by the invasiveness of bronchoscopy. Based on...
Lees meerPhase 2a randomised, double-blind, placebo-controlled study to evaluate the efficacy and safety of londamocitinib (AZD4604) two times per day for 12 weeks in adult patients with moderate-to-severe asthma uncontrolled on medium-high-dose ICS-LABA.
BMJ Open Respir Res. 2026 Mar;13(1)Asthma is a heterogeneous condition and affected individuals show variable responses to available medications. An unmet need exists for add-on...
Lees meerKey factors for implementing inhaler regimen switches in respiratory diseases: international expert consensus generated using a modified nominal group technique (NGT).
NPJ Prim Care Respir Med. 2026 Feb;To develop international expert consensus statements on when and how to implement inhaler switches for patients with asthma or chronic obstructive...
Lees meerSmall Airways Dysfunction and Remission in Adults With Asthma: A Longitudinal Exploratory Analysis of the AssessmenT of smalL Airways involvemeNT In aSthma (ATLANTIS) Study.
Allergy. 2026 Feb;Asthma remission is a feasible treatment goal. However, remission definitions vary, and predictive biomarkers remain underexplored.
Lees meerHealth status in patients with limited health literacy; development and validity of the Clinical COPD Questionnaire graphic (CCQg).
NPJ Prim Care Respir Med. 2026 Jan;36(1):1Patients with Chronic Obstructive Pulmonary Disease (COPD) often experience limited health literacy, hampering health status assessment via standard...
Lees meerNasal gene expression shows a distinct signature in type 2-high asthma but not in type 2-low disease.
J Allergy Clin Immunol. 2026 Jan;Type 2 (T2)-low asthma is defined by low levels of T2 inflammation and is associated with resistance to inhaled corticosteroids. Its molecular...
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