Our publications

Tiotropium/Olodaterol Delays Clinically Important Deterioration Compared with Tiotropium Monotherapy in Patients with Early COPD: a Post Hoc Analysis of the TONADO Trials.

Since chronic obstructive pulmonary disease (COPD) is a heterogeneous condition, a composite endpoint of clinically important deterioration (CID) may...

The use of a direct bronchial challenge test in primary care to diagnose asthma.

Many asthmatics in primary care have mild symptoms and lack airflow obstruction. If variable expiratory airflow limitation cannot be determined by...

Burden and socioeconomics of asthma, allergic rhinitis, atopic dermatitis and food allergy.

Asthma, allergic rhinitis, atopic dermatitis, and food allergy affect approximately 20% of the global population. Few studies describe the burden of...

The Long-Term Burden of COPD Exacerbations During Maintenance Therapy and Lung Function Decline.

Early identification of preventable risk factors of COPD progression is important. Whether exacerbations have a negative impact on disease...

Prevalence of Asthma Characteristics in COPD Patients in a Dutch Well-Established Asthma/COPD Service for Primary Care.

Primary care COPD guidelines indicate that COPD patients with asthma characteristics should be treated as having asthma. This study aims to describe...

Drug Burden Index and Cognitive and Physical Function in Aged Care Residents: A Longitudinal Study.

Anticholinergic/antimuscarinic and sedative medications (eg, benzodiazepines) have been found to be associated with poorer cognitive and physical...

Commentary: “Healthcare Professionals’ Preferred Efficacy Endpoints and Minimal Clinically Important Differences in the Assessment of New Medicines for Chronic Obstructive Pulmonary Disease” by Dankers M et al. in 2020; 10: 1519.

Adequacy of Therapy for People with Both COPD and Heart Failure in the UK: Historical Cohort Study.

Chronic obstructive pulmonary disease (COPD) and heart failure (HF) often occur concomitantly, presenting diagnostic and therapeutic challenges for...

Improving primary care management of asthma: do we know what really works?

Asthma imposes a substantial burden on individuals and societies. Patients with asthma need high-quality primary care management; however, evidence...

Association between COPD exacerbations and lung function decline during maintenance therapy.

Little is known about the impact of exacerbations on COPD progression or whether inhaled corticosteroid (ICS) use and blood eosinophil count (BEC)...

Quality of spirometry and related diagnosis in primary care with a focus on clinical use.

American and European societies' (ATS/ERS) criteria for spirometry are often not met in primary care. Yet, it is unknown if quality is sufficient for...

Likely questionnaire-diagnosed food allergy in 78, 890 adults from the northern Netherlands.

It is challenging to define likely food allergy (FA) in large populations which limited the number of large studies regarding risk factors for FA.